Postdose 3 G1 serum neutralizing antibody as correlate of protection for pentavalent rotavirus vaccine
نویسندگان
چکیده
منابع مشابه
Effectiveness of monovalent and pentavalent rotavirus vaccine.
OBJECTIVE Previous US evaluations have not assessed monovalent rotavirus vaccine (RV1, a G1P[8] human rotavirus strain) effectiveness, because of its later introduction (2008). Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose RV1 and 3-dose pentavalent vaccine (RV5) series against rotavirus disease resulting in hospital emergency department or inpatient c...
متن کاملCost effectiveness of a pentavalent rotavirus vaccine in Oman
BACKGROUND Rotavirus gastroenteritis (RGE) is the leading cause of diarrhea in young children in Oman, incurring substantial healthcare and economic burden. We propose to formally assess the potential cost effectiveness of implementing universal vaccination with a pentavalent rotavirus vaccine (RV5) on reducing the health care burden and costs associated with rotavirus gastroenteritis (RGE) in ...
متن کاملPentavalent rotavirus vaccine and prevention of gastroenteritis hospitalizations in Australia.
OBJECTIVE A publicly funded, universal infant pentavalent rotavirus vaccine (RV5) program was implemented in Queensland, Australia, in mid-2007. We sought to assess vaccine effectiveness (VE) of 3 doses of RV5 at preventing rotavirus and nonrotavirus acute gastroenteritis (AGE) hospitalizations in the first birth cohort and impact on hospitalizations in all age groups. METHODS Hospitalization...
متن کاملDuration of protection of pentavalent rotavirus vaccination in Nicaragua.
OBJECTIVE To evaluate the duration of protection of pentavaent rotavirus vaccine (RV5) against rotavirus hospitalizations in Nicaragua, a developing country in Central America. METHODS We conducted a case-control study at 4 hospitals from 2007 through 2010, including 1016 children hospitalized with laboratory-confirmed rotavirus diarrhea, 4930 controls with nonrotavirus diarrhea (ie, "test-ne...
متن کاملSerum antibody responses in children with rotavirus diarrhea can serve as proxy for protection.
We examined sera from 42 patients 1 to 30 months of age for rotavirus immunoglobulin M (IgM), IgA, IgG, and IgG subclasses and sought to determine if serum antibody could serve as a reliable marker for prediction of disease severity. Infants in the first few months of life usually had high maternal IgG titers and, when they were infected with rotavirus, had low IgM titers or no IgM in acute-pha...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2017
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2017.1356522